The movie
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Show notes
The Substance is a bloody, campy, fiercely feminist body horror film. Demi Moore plays a TV aerobics instructor desperate to stay in the spotlight. She learns of a mysterious drug she can inject that causes another, younger, entirely separate version of herself (Margaret Qualley) to splurt out of her back and assume her consciousness. They must switch back and forth or very bad bloody things will happen. Learn more about sponsor message choices: podcastchoices.com/adchoices NPR Privacy Policy
More episodes about The Substance
Oct 29, 2025 · 1h 13m
